PHILADELPHIA (Ticker) -- The New York Mets homered early and often to spoil Vicente Padilla 's season debut.

Jose Reyes and Victor Diaz each homered twice as the Mets belted a franchise-record seven en route to a 16-4 pounding of the Philadelphia Phillies .

Activated from the disabled list prior to the game after being sidelined with right triceps tendinitis, Padilla (0-1) fell behind quickly as Reyes belted the fourth pitch of the contest over the left field wall to give New York a 1-0 lead.

"That was my first time and I felt so happy about it," Reyes said of his first career leadoff homer. "I didn't think the ball was going to go out, so I turned to the umpire at second base and asked, 'Home run?' and he said, 'Yes.'"

The Phillies pulled even in the bottom half, but Diaz followed a one-out walk to David Wright in the second with a blast to center field, putting the Mets ahead, 3-1.

Chase Utley led off the bottom of the inning with his second homer of the season, but the Mets touched Padilla for three shots in the third - including Diaz's second two-run blast of the game - for a commanding 8-2 cushion.

"I got it on the fat part of the barrel," said Diaz, who recorded his first career multi-homer game. "It just flied out of there."

"We needed to jump out early. We've been kind of playing catch-up most of the year," Mets manager Willie Randolph said. "Even though (the Phillies) kind of matched runs with us early on, we still kept playing."

Reyes added a leadoff shot in the fourth and Wright belted his first career grand slam in the sixth as New York scored in each of the first six innings to build a 16-4 lead. It was the second career multi-homer performance by Reyes, who also accomplished the feat against Atlanta on August 28, 2003.

Mike Piazza and Doug Mientkiewicz also homered in the third for the Mets, who had recorded six home runs twice, most recently against Cincinnati on June 15, 1999. Piazza's blast was his 40th against the Phillies, his highest total against any team.

"We got some balls up in the air and drive it pretty good, but I liked the fact that we just kept adding on and kept battling," Randolph said.

"They had a real good night hitting," Philadelphia manager Charlie Manuel said. "It seemed like every ball they hit hard was up in the air and they put them in the seats. We just got beat pretty good."

Piazza's homer traveled an estimated 471 feet to left-center field, the second-longest distance in Citizens Bank Park's brief history. On May 18, Los Angeles' Jason Grabowski belted a shot 481 feet.

Mets starter Victor Zambrano even got involved in the offense, ripping a two-run triple in the fifth. It was just his third hit in 23 career at-bats.

"He didn't look too wift the first couple of at-bats, but I guess he laid the bat out there and it hit his bat," Randolph said.

"I hit it pretty nice, but I think the win is most important for the team," Zambrano said.

Zambrano (1-1) notched the win after allowing four runs - two earned - and eight hits in six innings. He walked three and struck out five.

"My concentration was in every pitch I threw, and throwing strikes was all I was thinking about," Zambrano said.

Padilla lasted just three innings, surrendering eight runs and eight hits in falling to 9-2 lifetime against the Mets.

"He just didn't hit his spots," Manuel said. "His stuff is still there. It's just a matter of him getting sharp and getting command of his pitches.

Rookie Gavin Floyd , who was removed from the rotation to make room for Padilla, also yielded eight runs in three frames.

"In a way, I'm worried about (Floyd's) confidence. But at the same time, He's going to pitch in that role," Manuel said. "We've got to get him into games and we've got to let him pitch. I think that he's man enough to handle that."